Dr. Maxwell Mamfe Sakyiamah

CPMR > H.O.D > Dr. Maxwell Mamfe Sakyiamah
PROFILE

Dr. Sakyiamah holds PhD in Medicinal Chemistry, MPhil and BSc in Biochemistry from the University of Ghana, Legon. He joined the Centre in 2010 as a Research Officer.

 

 

 

 

 

Research interest: 

  1. Drug discovery and development from natural products using chromatographic techniques: Bioactivity-guided fractionation, isolation and purification of compounds from medicinal plants with anti-viral, anti-parasitic, anti-diabetic, anti-hypertension, anti-cancer, anti-inflammatory activities etc.
  2. Generation of compound libraries for standardization and quality control of herbal medicines. Establish the pharmacokinetic parameters of isolated compounds from medicinal plants.
  3. Drug interactions (Herb-drug interaction): Effects of plant extracts on the pharmacokinetics, pharmacodynamics and metabolism of other drugs.
  4. Development of sensitive bioassay systems for high-throughput screening of compounds (peptides, synthesized small compounds and fractions/isolates from medicinal plants).
  5. Peptidomimetics (Design and synthesis of peptides for drug development targeting specific receptors/enzymes eg. chemokine receptor – CXCR4).
  6. Development of bio-probes with receptor – binding affinity for imaging (eg. Confocal laser scanning microscopy) applied in drug discovery.
  7. Structure-activity relationship studies (SARs) between receptors/enzymes and their ligands (natural products isolated from medicinal plants, synthesized small compounds and peptides).
  8. Bioremediation- improving the nutritional value and medicinal properties of plants/plant parts.

 

Publications

Sakyiamah, M.M., Nomura, W., Kobayakawa, T. and Tamamura, H. (2019) Development of a NanoBRET-based sensitive screening method for CXCR4 ligands, Bioconjugate Chem. 30, 1442-1450.

 

Sakyiamah, M.M., Kobayakawa, T., Fujino, M., Konno, M., Narumi, T., Tanaka, T., Nomura, W., Yamamoto, N., Murakami, T. and Tamamura, H. (2019) Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands, Bioorg. Med.Chem. 27, 1130-1138

Ohashi, M., Amoa-Bosompem, M.,  Kwofie, K.D., Agyapong, J., Adegle, R., Sakyiamah, M.M.,  Ayertey, F., Owusu, K.B., Tuffour, I., Atchoglo, P., Tung, N.H., Uto, T., Aboagye, F., Appiah, A.A., Appiah-Opong, R., Nyarko, A.K., Anyan, W.K., Ayi, I.,  Boakye, D.A., Koram, K.,  Edoh, D.,   Yamaoka, S., Shoyama, Y. and Ohta, N. (2018) In vitro antiprotozoan activity and mechanisms of action of selected Ghanaian medicinal plants against Trypanosoma, Leishmania, and Plasmodium parasites. Phytotherapy Research. 1–14. https://doi.org/10.1002/ ptr.6093

Sakyiamah, M.M., Brew-Daniels, H., Appiah, A.A. and Edoh, D. (2015) Herb-drug interaction: Effect of aqueous extract of Bridelia ferruginea leaves on the pharmacokinetics of metformin, J. Med. Herbs Ethnomed.1: 84-88

Kwofie, K.D., Tung, N.H., Suzuki-Ohashi, M., Amoa-Bosompem, M., Adegle, A., Sakyiamah, M.M., Ayertey, F., Baffuor-Awuah, O., Tuffuor, I., Atchoglo, P., Frempong, K.K., Ayan, W.K., Uto, T., Morinaga, O., Yamashhita, T.,  Aboagye, F., Appiah, A.A., Appiah-Oppong, R., Nyarko, A.K., Yasuchika, Y., Edoh, D., Koram, K.A., Yamaoka, S., Boakye, D.A ., Ohta, N., Shoyama, Y. and Ayi, I (2016) Antitrypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth. Antimicrob Agents Chemother 60:3283–3290

Suzuki, M., Tung, N.H., Kwofie, K.D., Adegle, R., Amoa-Bosompem, M., Sakyiamah, M., Ayertey, F., Owusu, K.B., Tuffour, I., Atchoglo, P., Frempong, K.K., Anyan, W.K., Uto, T., Morinaga, O.,  Yamashita, T., Aboagye, F.,  Appiah, A.A., Appiah-Opong,  R., Nyarko, A.K., Yamaoka, S.,  Yamaguchi, Y., Edoh, D., Koram, K., Ohta, N.,  Boakye, D.A., Ayi, I. and Shoyama, Y. (2015) New anti-trypanosomal active tetracyclic iridoid isolated from Morinda lucida Benth. Bioorg Med Chem Lett. 25(15):3030-3.

 

Thomford, K.P., Mensah, M.L.K., Dickson, R.A., Sakyiamah, M., Edoh, D.A. and Annan, K. (2015). Determination of the Rutin, Quercetin and Kaempferol Contents in a Ghanaian polyherbal Formulation (EAF-2011) and Its raw materials using a simultaneous RP-HPLC Method. Int. J. Pharm. Sci. Drug Res. 7(1): 96-99

Hori, T., Barnor, J., Huu, T.N., Morinaga, O., Hamano, A., Ndzinu, J., Frimpong, A., Minta-Asare, K., Amoa-Bosompem, M., Brandful, J., Odoom, J., Bonney, J., Tuffuor, I., Baffuor-Awuah, O., ofosuhene, M., Atchoglo, P., Sakyiamah, M., Adegle, R., Appiah-Oppong, R. Ampofo, W., Koram, K., Nyarko, A., Okine, L, Edoh, E., Appiah, A., Uto, T., Yoshinaka, Y., Uota, S., Shoyama, Y. and Yamaoka, S. (2015) Procyanidin trimer C1 derived from Theobroma cacao reactivates latent human immunodeficiency virus type 1 provirus. Biochem. Biophys. Res. Comm. 459, 288e293

Ocloo, A., Okpattah, W. E., Quasie, O., Sakyiamah, M. M. and. Okine, L. K. N. (2014). Concurrent administration of aqueous extract of Cryptolepis sanguinolenta reduces the effectiveness of artesunate against Plasmodium berghei in rats. J App Pharm Sci; 4 (03): 024-028.

Sarkodie, J.A., Appiah, A.A., Edoh, D.A., Aboagye, F.A., Asiedu-Larbi, J., Tandoh, M., Sakyiamah, M. and Donkor, K. (2014) Antihyperglycaemic and antioxidant effects of Croton membranaceus mull. Arg (euphorbiaceae) IJPSR, 5(1): 110-115.

Sarkodie, J.A., Edoh, D.A., Sakyiamah, M., Appiah, A.A., Antwi, S., Nyarko, A.K., Owusu, P.D., Debrah, P., Jackson, N.A.B. and Amoateng, P. (2013). Comparative study of the hypoglycaemic property of Magnifera indica leaves in Streptozotocin- induced diabetic rats and genetic diabetic mice. SPJPBS 1:37-42

Ocloo, A, Sakyiamah, M.M., Adjimani, J.P. and Sittie, A. (2012). Aqueous Extract of Cryptolepis sanguinolenta enhance cytochrome P450 1A isozyme activity in the presence of Artesunate. GJMR 12(5):15-21.

Sakyiamah, M.M., Ocloo, A., Adjimani, J.P. and Sittie, A. (2012). Effect of aqueous extract of Cryptolepis sanguinolenta on the Pharmacokinetics of chloroquine. Int. J. Drug Res. Tech. 2 (4S): 378-387

Sakyiamah, M.M., Ocloo, A., Adjimani, J.P. and Sittie, A. (2011). Effect of Aqueous Extract of Cryptolepis sanguinolenta on the Pharmacokinetics of Artesunate. IJPSDR 3(4):313-318

Adamafio, N. A., Sakyiamah, M. M. and Tettey, J. (2010). Fermentation in Cassava (Manihot esculenta Crantz) pulp juice improves nutritive value of cassava peel. Afr. J. Biochem. Res 4(3) pp. 51-56